Developing an effective computer-aided diagnosis (CAD) system for lung cancer is of great clinical importance and can significantly increase the patient's chance for survival. For this reason, CAD systems for lung cancer have been investigated in a large number of research studies. A typical CAD system for lung cancer diagnosis is composed of four main processing steps: segmentation of the lung fields, detection of nodules inside the lung fields, segmentation of the detected nodules, and diagnosis of the nodules as benign or malignant. This book overviews the current state-of-the-art techniques that have been developed to implement each of these CAD processing steps. Overviews the latest state-of-the-art diagnostic CAD systems for lung cancer imaging and diagnosis Offers detailed coverage of 3D and 4D image segmentation Illustrates unique fully automated detection systems coupled with 4D Computed Tomography (CT) Written by authors who are world-class researchers in the biomedical imaging sciences Includes extensive references at the end of each chapter to enhance further study Ayman El-Baz is a professor, university scholar, and chair of the Bioengineering Department at the University of Louisville, Louisville, Kentucky. He earned his bachelor's and master's degrees in electrical engineering in 1997 and 2001, respectively. He earned his doctoral degree in electrical engineering from the University of Louisville in 2006. In 2009, he was named a Coulter Fellow for his contributions to the field of biomedical translational research. He has 17 years of hands-on experience in the fields of bio-imaging modeling and noninvasive computer-assisted diagnosis systems. He has authored or coauthored more than 500 technical articles (132 journals, 23 books, 57 book chapters, 211 refereed-conference papers, 137 abstracts, and 27 U.S. patents and disclosures). Jasjit S. Suri is an innovator, scientist, a visionary, an industrialist, and an internationally known world leader in biomedical engineering. He has spent over 25 years in the field of biomedical engineering/devices and its management. He received his doctorate from the University of Washington, Seattle, and his business management sciences degree from Weatherhead School of Management, Case Western Reserve University, Cleveland, Ohio. He was awarded the President's Gold Medal in 1980 and named a Fellow of the American Institute of Medical and Biological Engineering for his outstanding contributions in 2004. In 2018, he was awarded the Marquis Life Time Achievement Award for his outstanding contributions and dedication to medical imaging and its management.

Neuro-oncology broadly encompasses life-threatening brain and spinal cord malignancies, including primary lesions and lesions metastasizing to the central nervous system. It is well suited for diagnosis, classification, and prognosis as well as assessing treatment response. Radiomics and Radiogenomics (R-n-R) have become two central pillars in precision medicine for neuro-oncology.Radiomics is an approach to medical imaging used to extract many quantitative imaging features using different data characterization algorithms, while Radiogenomics, which has recently emerged as a novel mechanism in neuro-oncology research, focuses on the relationship of imaging phenotype and genetics of cancer. Due to the exponential progress of different computational algorithms, AI methods are composed to advance the precision of diagnostic and therapeutic approaches in neuro-oncology.The field of radiomics has been and definitely will remain at the lead of this emerging discipline due to its efficiency in the field of neuro-oncology. Several AI approaches applied to conventional and advanced medical imaging data from the perspective of radiomics are very efficient for tasks such as survival prediction, heterogeneity analysis of cancer, pseudo progression analysis, and infiltrating tumors. Radiogenomics advances our understanding and knowledge of cancer biology, letting noninvasive sampling of the molecular atmosphere with high spatial resolution along with a systems-level understanding of causal heterogeneous molecular and cellular processes. These AI-based R-n-R tools have the potential to stratify patients into more precise initial diagnostic and therapeutic pathways and permit better dynamic treatment monitoring in this period of personalized medicine. While extremely promising, the clinical acceptance of R-n-R methods and approaches will primarily hinge on their resilience to non-standardization across imaging protocols and their capability to show reproducibility across large multi-institutional cohorts.Radiomics and Radiogenomics in Neuro-Oncology: An Artificial Intelligence Paradigm provides readers with a broad and detailed framework for R-n-R approaches with AI in neuro-oncology, the description of cancer biology and genomics study of cancer, and the methods usually implemented for analyzing. Readers will also learn about the current solutions R-n-R can offer for personalized treatments of patients, limitations, and prospects. There is comprehensive coverage of information based on radiomics, radiogenomics, cancer biology, and medical image analysis viewpoints on neuro-oncology, so this in-depth coverage is divided into two Volumes.Volume 1: Radiogenomics Flow Using Artificial Intelligence provides coverage of genomics and molecular study of brain cancer, medical imaging modalities and analysis in neuro-oncology, and prognostic and predictive models using radiomics.Volume 2: Genetics and Clinical Applications provides coverage of imaging signatures for brain cancer molecular characteristics, clinical applications of R-n-R in neuro-oncology, and Machine Learning and Deep Learning AI approaches for R-n-R in neuro-oncology.

The book covers novel strategies of state of the art in engineering and clinical analysis and approaches for analyzing abdominal imaging, including lung, mediastinum, pleura, liver, kidney and gallbladder. In the last years the imaging techniques have experienced a tremendous improvement in the diagnosis and characterization of the pathologies that affect abdominal organs. In particular, the introduction of extremely fast CT scanners and high Magnetic field MR Systems allow imaging with an exquisite level of detail the anatomy and pathology of liver, kidney, pancreas, gallbladder as well as lung and mediastinum. Moreover, thanks to the development of powerful computer hardware and advanced mathematical algorithms the quantitative and automated\semi automated diagnosis of the pathology is becoming a reality. Medical image analysis plays an essential role in the medical imaging field, including computer-aided diagnosis, organ/lesion segmentation, image registration, and image-guided therapy. This book will cover all the imaging techniques, potential for applying such imaging clinically, and offer present and future applications as applied to the abdomen and thoracic imaging with the most world renowned scientists in these fields. The main aim of this book is to help advance scientific research within the broad field of abdominal imaging. This book focuses on major trends and challenges in this area, and it presents work aimed to identify new techniques and their use in medical imaging analysis for abdominal imaging.

This book deals with the acquisition and extraction of the various morphological features of the electrocardiogram signals.

In the first chapters the book first presents data fusion and different data mining techniques that have been used for the cardiac state diagnosis. The second part deals with heart rate variability (HRV), a non-invasive measurement of cardiovascular autonomic regulation.

Next, visualization of ECG data is discussed, an important part of the display in life threatening state. Here, the handling of data is discussed which were acquired during several hours.

In the following chapters the book discusses aortic pressure measurement which is of significant clinical importance. It presents non-invasive methods for analysis of the aortic pressure waveform, indicating how it can be employed to determine cardiac contractility, arterial compliance, and peripheral resistance. In addition, the book demonstrates methods to extract diagnostic parameters for assessing cardiac function. Further the measurement strategies for contractile effort of the left ventricle are presented.

Finally, the book concludes about the future of cardiac signal processing leading to next generation research topics which directly impacts the cardiac health care.

The editors thank Biocom Technologies for the provided scientific material and help in writing the book.